New coumarin derivatives accessible in short and eco-friendly conditions with antifungal activity - Normandie Université Accéder directement au contenu
Article Dans Une Revue Future Medicinal Chemistry Année : 2023

New coumarin derivatives accessible in short and eco-friendly conditions with antifungal activity

Résumé

Aim: The synthesis of a novel class of compounds bearing a coumarin entity was targeted. They are either iminocoumarins or characterized by the presence of a pyridone ring fused within the iminocoumarin scaffold. Methods & results: The targeted compounds were synthesized through a short method, thanks to microwave activation. The study evaluated the antifungal activity of 13 newly synthesized compounds against a new fungal strain of Aspergillus niger. The most active compound showed activity comparable to the widely used reference drug, amphotericin B. Conclusion: The conditions and the ease of synthesis warrant high potential of the method for diversity-oriented synthesis, very useful within the drug discovery area.
Fichier principal
Vignette du fichier
452hall.pdf (147.46 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04265827 , version 1 (31-10-2023)

Licence

Copyright (Tous droits réservés)

Identifiants

Citer

Siham Benanane, Nawel Cheikh, Nour El-Houda Bendhina, Didier Villemin, Ahcène Boumendjel. New coumarin derivatives accessible in short and eco-friendly conditions with antifungal activity. Future Medicinal Chemistry, 2023, 15 (9), pp.745-756. ⟨10.4155/fmc-2023-0033⟩. ⟨hal-04265827⟩
29 Consultations
19 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More