Article Dans Une Revue Future Medicinal Chemistry Année : 2023

New coumarin derivatives accessible in short and eco-friendly conditions with antifungal activity

Résumé

Aim: The synthesis of a novel class of compounds bearing a coumarin entity was targeted. They are either iminocoumarins or characterized by the presence of a pyridone ring fused within the iminocoumarin scaffold. Methods & results: The targeted compounds were synthesized through a short method, thanks to microwave activation. The study evaluated the antifungal activity of 13 newly synthesized compounds against a new fungal strain of Aspergillus niger. The most active compound showed activity comparable to the widely used reference drug, amphotericin B. Conclusion: The conditions and the ease of synthesis warrant high potential of the method for diversity-oriented synthesis, very useful within the drug discovery area.

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hal-04265827 , version 1 (31-10-2023)

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Siham Benanane, Nawel Cheikh, Nour El-Houda Bendhina, Didier Villemin, Ahcène Boumendjel. New coumarin derivatives accessible in short and eco-friendly conditions with antifungal activity. Future Medicinal Chemistry, 2023, 15 (9), pp.745-756. ⟨10.4155/fmc-2023-0033⟩. ⟨hal-04265827⟩
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