An Organocatalytic and Stereoselective Vinylogous Domino Process Towards Thiochromans
Abstract
A highly diastereoselective organocatalyzed domino Vinylogous sulfa-Michael-Aldol-Cyclocondensation (VMAC) reaction has been developed using alkylidene Meldrum’s acid as dienes highlighting two vinylogous steps, an unprecedented sulfa-1,6-conjugate addition and a diastereoselective aldol reaction triggering a formal (4+2) cycloaddition. This work opens a new route to bio-relevant and original tricyclic thiochroman derivatives.
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