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Document Associé À Des Manifestations Scientifiques Année : 2023

Microwave Activation: Solventless Catalysed Synthesis of Cross Conjugated Dienones of Tropinone

Renata Gasparova

Résumé

Cross-conjugated dienones are very important biologically active products. The condensation of N-methyl-8-azabicyclo[3.2.1]-bicyclo[3.2.1]octan-3-one (tropinone) with aromatic aldehydes takes place in the presence of acidic (K10 clay, silica) or basic catalysts (alumina, KF-alumina). The best yields of (2E,4E)-2,4-bis-arylmethylene-8-methyl-8-azabicyclo[3.2.1]octan-3-ones were obtained with the K10 clay under microwave irradiation without solvent. New dienones derived from tropinone will be tested in various biological assays.
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hal-04416032 , version 1 (25-01-2024)

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Renata Gasparova, Didier Villemin, Nathalie Bar. Microwave Activation: Solventless Catalysed Synthesis of Cross Conjugated Dienones of Tropinone. 2023, ⟨10.3390/ecsoc-27-16155⟩. ⟨hal-04416032⟩
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