Oxetane Ring‐Opening Reaction: A Key Step for the Preparation of Substituted (Fluoro)alkenyl as Acyclonucleoside Mimics - Normandie Université Accéder directement au contenu
Article Dans Une Revue European Journal of Organic Chemistry Année : 2023

Oxetane Ring‐Opening Reaction: A Key Step for the Preparation of Substituted (Fluoro)alkenyl as Acyclonucleoside Mimics

Résumé

Abstract Tri‐ and tetra‐substituted alkenes, including fluoroalkenes, were prepared by a selective ring‐opening reaction of functionalized oxetanes. The introduction of adenine nucleic base allows the synthesis of alkenyl and fluoroalkenyl derivatives that were evaluated towards DltA enzyme as potential nucleoside mimics.
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hal-04391576 , version 1 (12-01-2024)

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David Leparfait, Feng Xiao, Delphine Coupri, Sabrina Gueulle, Florie Desriac, et al.. Oxetane Ring‐Opening Reaction: A Key Step for the Preparation of Substituted (Fluoro)alkenyl as Acyclonucleoside Mimics. European Journal of Organic Chemistry, 2023, 26 (21), ⟨10.1002/ejoc.202300258⟩. ⟨hal-04391576⟩
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