Ring-Closing Synthesis of Dibenzothiophene Sulfonium Salts and Their Use as Leaving Groups for Aromatic 18 F-Fluorination - Normandie Université Accéder directement au contenu
Article Dans Une Revue Journal of the American Chemical Society Année : 2018

Ring-Closing Synthesis of Dibenzothiophene Sulfonium Salts and Their Use as Leaving Groups for Aromatic 18 F-Fluorination

Résumé

Herein, we report a novel intramolecular ring-closing reaction of biaryl thioethers that give access to highly functionalized dibenzothiophene sulfonium salts under mild conditions. The resulting precursors react regioselectively with [18F]fluoride to give [18F]fluoroarenes in predictable radiochemical yields. The strategy expands the available radiochemical space and provides superior labeling efficiency for clinically relevant PET tracers.

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Chimie

Dates et versions

hal-04344457 , version 1 (14-12-2023)

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Thibault Gendron, Kerstin Sander, Klaudia Cybulska, Laure Benhamou, Pak Kwan Brian Sin, et al.. Ring-Closing Synthesis of Dibenzothiophene Sulfonium Salts and Their Use as Leaving Groups for Aromatic 18 F-Fluorination. Journal of the American Chemical Society, 2018, 140 (35), pp.11125-11132. ⟨10.1021/jacs.8b06730⟩. ⟨hal-04344457⟩

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