Human rheumatoid synovial cells (HRSC) in culture express TGF-β receptors and are growth stimulated by the factor - Normandie Université Accéder directement au contenu
Poster De Conférence Année : 1992

Human rheumatoid synovial cells (HRSC) in culture express TGF-β receptors and are growth stimulated by the factor

Résumé

TGF-β (5 ng/ml) increased the proliferation rate of HRSC by 30 % after 96 h of treatment. One type of TGF-β binding system, with apparent Kd of 953 pM and a number of 29400 receptors/cell, was detected by Scatchard analysis of [125I]-TGF-β binding. Howewer, crosslinking experiments and SDS-PAGE separation showed five TGF-β binding proteins: 50, 70, 110, 140 and 400 kDa. We may suggest that the affinities of these receptors are too close to be revealed by-Scatchard plot. All together, the data suggest that TGF-β plays a role in the hyperplasia of RA synovial tissue.
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Dates et versions

hal-04228198 , version 1 (04-10-2023)

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  • HAL Id : hal-04228198 , version 1

Citer

Stéphane Pronost, Françoise Rédini, Denis Vivien, Philippe Galéra, Jean Pierre Pujol. Human rheumatoid synovial cells (HRSC) in culture express TGF-β receptors and are growth stimulated by the factor. Joint Destruction in Arthritis and Osteoarthritis, May 1992, Noordwijkerhout, Netherlands. Agents and Actions, 39 (SUPPL), pp.133-137, 1993. ⟨hal-04228198⟩
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