Determinants of IBD-related disability: a cross-sectional survey from the GETAID.
Jenny Tannoury
(1)
,
Maria Nachury
(2)
,
Carole Martins
(3)
,
Melanie Serrero
(4)
,
Jerome Filippi
(5)
,
Xavier Roblin
(6)
,
Anne Bourrier
(7)
,
Guillaume Bouguen
(8, 9)
,
Denis Franchimont
(10)
,
Guillaume Savoye
(11, 12, 13, 14)
,
Anthony Buisson
(15)
,
Edouard Louis
(16)
,
Stephane Nancey
(17)
,
Vered Abitbol
(7)
,
Jean-Marie Reimund
(18)
,
Olivier Dewitt
(10)
,
Lucine Vuitton
(19)
,
Nicolas Mathieu
(20)
,
Laurent Peyrin-Biroulet
(21)
,
Cyrielle Gilletta
(22)
,
Matthieu Allez
(7)
,
Stephanie Viennot
(23)
,
Caroline Trang-Poisson
(24)
,
David Laharie
(25)
,
Aurelien Amiot
(1)
,
Groupe d'Etude Thérapeutique Des Affections Getaid
1
Service d'hépato-gastro-entérologie [APHP Henri Mondor]
2 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
3 CHU Clichy
4 CHU Marseille
5 CHU Nice - Centre Hospitalier Universitaire de Nice
6 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
7 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
8 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
9 NuMeCan - Nutrition, Métabolismes et Cancer
10 HUB-ULB - Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis
11 ADEN - Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau
12 IRIB - Institute for Research and Innovation in Biomedicine
13 Service d'Hépato-Gastroentérologie [CHU Rouen]
14 UNIROUEN UFR Santé - UNIROUEN - UFR Santé
15 CHU Clermont-Ferrand
16 CHU-Liège - Centre Hospitalier Universitaire de Liège
17 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
18 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
19 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
20 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
21 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
22 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
23 Service d'Hépato-Gastro-Enterologie et Nutrition [CHU Caen]
24 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
25 CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux
2 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
3 CHU Clichy
4 CHU Marseille
5 CHU Nice - Centre Hospitalier Universitaire de Nice
6 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
7 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
8 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
9 NuMeCan - Nutrition, Métabolismes et Cancer
10 HUB-ULB - Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis
11 ADEN - Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau
12 IRIB - Institute for Research and Innovation in Biomedicine
13 Service d'Hépato-Gastroentérologie [CHU Rouen]
14 UNIROUEN UFR Santé - UNIROUEN - UFR Santé
15 CHU Clermont-Ferrand
16 CHU-Liège - Centre Hospitalier Universitaire de Liège
17 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
18 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
19 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
20 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
21 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
22 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
23 Service d'Hépato-Gastro-Enterologie et Nutrition [CHU Caen]
24 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
25 CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux
Anthony Buisson
- Fonction : Auteur
- PersonId : 763185
- ORCID : 0000-0002-6347-409X
- IdRef : 167502484
Stephane Nancey
- Fonction : Auteur
- PersonId : 928425
- ORCID : 0000-0003-2088-1442
Laurent Peyrin-Biroulet
- Fonction : Auteur
- PersonId : 1111110
- ORCID : 0000-0003-2536-6618
- IdRef : 087640147
Matthieu Allez
- Fonction : Auteur
- PersonId : 762385
- ORCID : 0000-0002-2012-7522
- IdRef : 050201581
Aurelien Amiot
Connectez-vous pour contacter l'auteur
- Fonction : Auteur correspondant
- PersonId : 1010648
- ORCID : 0000-0001-6676-1222
Connectez-vous pour contacter l'auteur
Groupe d'Etude Thérapeutique Des Affections Getaid
- Fonction : Auteur
Résumé
Background: The burden of inflammatory bowel disease (IBD) is rising worldwide. The goal of IBD treatment is to achieve clinical and endoscopic remission but also prevent disability.
Aims: To identify the predictive factors of disability in a large population of patients with IBD.
Patients and methods: We conducted a cross-sectional survey in 42 tertiary centres in France and Belgium. A self-administered questionnaire was designed to explore patients and their IBD characteristics. IBD-disk is a validated tool to measure disability in patients with IBD. The IBD-disk score was then calculated for each patient. Based on a previous study, an overall IBD-disk score ≥40 was associated with moderate-to-severe disability.
Results: Among the 2011 patients, 1700 were analysed, including 746 (44%) in self-reported clinical remission and 752 (44.2%) declaring clinical activity. The patient global assessment of global remission was missing in 200 (11.8%) of 1700 patients. Moderate-to-severe disability was significantly increased in patients with BMI >25 kg/m2 (OR = 1.66; 95% CI [1.29-2.14]), in those having perception of need for a psychotherapist (OR = 2.24; 95% CI [1.79-3.05]) and social worker (OR = 1.54; 95% CI [1.08-2.21]). Conversely, male gender (OR = 0.83; 95% CI [0.69-0.99]), ulcerative colitis (OR = 0.69; 95% CI [0.53-0.92]), self-reported clinical remission (OR = 0.59; 95% CI [0.46-0.77]) and employed or student occupational status (OR = 0.69; 95% CI [0.52-0.92]) were inversely correlated with disability. Overall, 257 (34.5%) patients who declared being in clinical remission had disability.
Conclusion: Determinants of IBD-related disability include IBD-related factors but also psychological and social factors. This highlights the importance of a multidisciplinary team in the management of patients with IBD.