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Article Dans Une Revue Arthritis and Rheumatism Année : 1993

Transforming growth factor β exerts opposite effects from interleukin-1β on cultured rabbit articular chondrocytes through reduction of interleukin-1 receptor expression

Résumé

Objective: The aim of the study was to determine whether transforming growth factor beta (TGF beta) modulates the effects and the receptor expression of interleukin-1 (IL-1) in rabbit articular chondrocytes (RAC). Methods: Collagen, glycosaminoglycan, and collagenase production, together with 125I-labeled IL-1 binding, were analyzed in RAC cultures. Results: TGF beta reduced both IL-1 effects on matrix metabolism and IL-1 receptor expression. Conclusion: TGF beta acts as an antagonist of the effects of IL-1 through down-regulation of its receptor expression.

Dates et versions

hal-04168376 , version 1 (21-07-2023)

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Françoise Rédini, Alain Mauviel, Stéphane Pronost, Gérard Loyau, Jean-Pierre Pujol. Transforming growth factor β exerts opposite effects from interleukin-1β on cultured rabbit articular chondrocytes through reduction of interleukin-1 receptor expression. Arthritis and Rheumatism, 1993, 36 (1), pp.44-50. ⟨10.1002/art.1780360108⟩. ⟨hal-04168376⟩
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