Evidence of a New Crystalline Phase of Prednisolone Obtained from the Study of the Hydration–Dehydration Mechanisms of the Sesquihydrate - Normandie Université Accéder directement au contenu
Article Dans Une Revue Pharmaceutics Année : 2023

Evidence of a New Crystalline Phase of Prednisolone Obtained from the Study of the Hydration–Dehydration Mechanisms of the Sesquihydrate

Résumé

The dehydration of prednisolone sesquihydrate is studied and characterized by different physico-chemical analysis methods. The meticulous study of this dehydration led to the highlighting of a new solid form (form 3), metastable, never identified before. In a second step, the rehydration of anhydrous forms 1 and 2 of prednisolone is studied, in particular by Dynamic Vapor Sorption. It is then demonstrated that neither of the two forms is sensitive to humidity. By means of solid-gas equilibria, the sesquihydrate can only be obtainable from the isomorphic anhydrous form. Finally, a classification of the sesquihydrate is made, taking into account, in particular, the activation energy determined during dehydration.
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hal-04123331 , version 1 (09-06-2023)

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Aurélien Lemercier, Nicolas Couvrat, Yohann Cartigny, Morgane Sanselme, Yohann Corvis, et al.. Evidence of a New Crystalline Phase of Prednisolone Obtained from the Study of the Hydration–Dehydration Mechanisms of the Sesquihydrate. Pharmaceutics, 2023, 15 (6), pp.1694. ⟨10.3390/pharmaceutics15061694⟩. ⟨hal-04123331⟩
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