Equine osteoarthritis: Strategies to enhance mesenchymal stromal cell-based acellular therapies - Normandie Université Accéder directement au contenu
Article Dans Une Revue Frontiers in Veterinary Science Année : 2023

Equine osteoarthritis: Strategies to enhance mesenchymal stromal cell-based acellular therapies

Résumé

Osteoarthritis (OA) is a degenerative disease that eventually leads to the complete degradation of articular cartilage. Articular cartilage has limited intrinsic capacity for self-repair and, to date, there is no curative treatment for OA. Humans and horses have a similar articular cartilage and OA etiology. Thus, in the context of a One Health approach, progress in the treatment of equine OA can help improve horse health and can also constitute preclinical studies for human medicine. Furthermore, equine OA affects horse welfare and leads to significant financial losses in the equine industry. In the last few years, the immunomodulatory and cartilage regenerative potentials of mesenchymal stromal cells (MSCs) have been demonstrated, but have also raised several concerns. However, most of MSC therapeutic properties are contained in their secretome, particularly in their extracellular vesicles (EVs), a promising avenue for acellular therapy. From tissue origin to in vitro culture methods, various aspects must be taken into consideration to optimize MSC secretome potential for OA treatment. Immunomodulatory and regenerative properties of MSCs can also be enhanced by recreating a pro-inflammatory environment to mimic an in vivo pathological setting, but more unusual methods also deserve to be investigated. Altogether, these strategies hold substantial potential for the development of MSC secretome-based therapies suitable for OA management. The aim of this mini review is to survey the most recent advances on MSC secretome research with regard to equine OA.
Fichier principal
Vignette du fichier
fvets-10-1115774.pdf (700.18 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

hal-04042900 , version 1 (23-03-2023)

Identifiants

Citer

Manon Jammes, Romain Contentin, Frédéric Cassé, Philippe Galéra. Equine osteoarthritis: Strategies to enhance mesenchymal stromal cell-based acellular therapies. Frontiers in Veterinary Science, 2023, 10 (1115774), ⟨10.3389/fvets.2023.1115774⟩. ⟨hal-04042900⟩
56 Consultations
30 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More