Petroleum in pesticides: a need to change regulatory toxicology. - Normandie Université Access content directly
Journal Articles Toxics Year : 2022

Petroleum in pesticides: a need to change regulatory toxicology.


Toxicological investigations of pesticides largely focus on the declared active ingredient, which constitutes only between a few percent to around 50% of the total formulation. The complete formulations are unknown. For each declared active ingredient, there are dozens or hundreds of formulations. We demonstrate that petroleum has always been and is still always in pesticides. Gas chromatography and mass spectrometry (GC-MS) were applied for 24 pesticides. The measured compounds were the 16-priority polycyclic aromatic hydrocarbons (PAHs). The ratio of the PAHs to the threshold of toxicity was from 2.16 to 8288 times. The levels and distribution of PAHs per pesticide were different. Petroleum residues appear to be a waste product. The declared active component is taken alone for toxicity calculations, such as the acceptable daily intake (ADI). The PAHs with 2–3 cycles are more represented in pesticides than those with 4–6 cycles, which underlines that the petroleum residues appear to come mainly from crude unburned material. The ADI should be divided by 1000 if it is considered that petroleum residues amplify the toxicity by 1000. The admixture of PAHs in pesticides can be highly carcinogenic or toxic in the long term, even more than the declared active ingredient itself.
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hal-04011969 , version 1 (31-05-2024)




Gérald Jungers, Florence Portet-Koltalo, Julie Cosme, Gilles-Eric Seralini. Petroleum in pesticides: a need to change regulatory toxicology.. Toxics, 2022, 10 (11), pp.670. ⟨10.3390/toxics10110670⟩. ⟨hal-04011969⟩
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