Radical Amido‐ and Azido‐Fluorination of α‐Fluorostyrene Derivatives: An Innovative Approach Towards β‐Aryl‐β,β‐difluoroamino Motifs
Résumé
An innovative one-step synthesis towards β-aryl-β,β-difluorocarbamates and β-aryl-β,β-difluoroazides is presented. The described approach relies on the use of α-fluorostyrene substrates in a radical addition/fluorination reaction with N-centered radicals in the presence of Selectfluor®. The best results were obtained for the azidofluorination reaction. The resultant β-arylβ,β-difluoroazides were further transformed into Nitrogenbased heterocycles (e. g. pyrrole, triazole, and tetrazole) and in more elaborated azide derivatives.
Domaines
Chimie organique
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Eur J Org Chem - 2022 - Ngo Ndimba - Radical Amido‐ and Azido‐Fluorination of ‐Fluorostyrene Derivatives An Innovative (1).pdf (5.61 Mo)
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