Synthesis and Biological Evaluation of New Chromenes and Chromeno[2,3-d] pyrimidines - Normandie Université Access content directly
Journal Articles South African Journal of Chemistry Year : 2021

Synthesis and Biological Evaluation of New Chromenes and Chromeno[2,3-d] pyrimidines

Fatima Belhadj
  • Function : Author
Zahira Kibou
  • Function : Author
Mohammed Benabdallah
  • Function : Author
Mohammed Aissaoui
  • Function : Author
Mohammed Nadjib Rahmoun
  • Function : Author
Noureddine Choukchou-Braham
  • Function : Author

Abstract

A simple and efficient approach has been developed to synthesise novel and functionalised 5H-chromeno[2,3-d] pyrimidines derivatives (4a-h). This approach entails treating 2-amino-3-cyano-4H-chromenes (3a-h) with formamidine acetate under microwave irradiations and solvent-free conditions. All structures of new compounds obtained in this study were characterised by IR, MS, 1H and 13C NMR analysis. Additionally, the synthesised compounds were investigated for their antibacterial and antioxidant potential. Compounds 3b, 3c, 3e, 4c and 4e showed significant activities. 10.17159/0379-4350/2021/v75a18
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Dates and versions

hal-03510392 , version 1 (04-01-2022)

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Fatima Belhadj, Zahira Kibou, Mohammed Benabdallah, Mohammed Aissaoui, Mohammed Nadjib Rahmoun, et al.. Synthesis and Biological Evaluation of New Chromenes and Chromeno[2,3-d] pyrimidines. South African Journal of Chemistry, 2021, 75, pp.150-151. ⟨10.17159/0379-4350/2021/v75a18⟩. ⟨hal-03510392⟩
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