Globetrotting strangles: the unbridled national and international transmission of Streptococcus equi between horses
Catriona Mitchell
(1)
,
Karen Steward
(1, 2)
,
Amelia Charbonneau
(1, 3)
,
Saoirse Walsh
(1, 4)
,
Hayley Wilson
(1, 5)
,
John Timoney
(6)
,
Ulli Wernery
(7)
,
Marina Joseph
(7)
,
David Craig
(8)
,
Kees van Maanen
(9)
,
Annelies Hoogkamer-van Gennep
(9)
,
Albertine Léon
(10, 11)
,
Lucjan Witkowski
(12)
,
Magdalena Rzewuska
(12)
,
Ilona Stefańska
(12)
,
Monika Żychska
(12)
,
Gunther van Loon
(13)
,
Ray Cursons
(14)
,
Olivia Patty
(14)
,
Els Acke
(15)
,
James Gilkerson
(16)
,
Charles El-Hage
(16)
,
Joanne Allen
(17)
,
Hiroshi Bannai
(17)
,
Yuta Kinoshita
(17)
,
Hidekazu Niwa
(17)
,
Teótimo Becú
(18)
,
John Pringle
(19)
,
Bengt Guss
(19)
,
Reinhard Böse
(20)
,
Yvonne Abbott
(21)
,
Lisa Katz
(21)
,
Bernadette Leggett
(21)
,
Tom Buckley
(22)
,
Shlomo Blum
(23)
,
Fátima Cruz López
(24)
,
Ana Fernández Ros
(25)
,
Maria Cristina Marotti Campi
(26)
,
Silvia Preziuso
(27)
,
Carl Robinson
(1)
,
J. Richard Newton
(1)
,
Ellen Schofield
(1, 5)
,
Ben Brooke
(1)
,
Mike Boursnell
(1)
,
Nicolas de Brauwere
(28)
,
Roxane Kirton
(28, 29)
,
Charlotte Barton
(30)
,
Khalil Abudahab
(31, 32)
,
Ben Taylor
(31, 32)
,
Corin Yeats
(31, 32)
,
Richard Goater
(31, 32)
,
David Aanensen
(31, 32)
,
Simon Harris
(31, 33)
,
Julian Parkhill
(5)
,
Matthew Holden
(31, 34)
,
Andrew Waller
(1, 35, 19)
1
AHT -
Animal Health Trust
2 Technology Networks
3 Xampla
4 FU - Free University of Berlin
5 CAM - University of Cambridge [UK]
6 Department of Veterinary Science, Gluck Equine Research Center
7 CVRL - Central Veterinary Research Laboratory
8 Emirates Racing Authority
9 Animal Health Service (GD)
10 LABÉO - LABÉO, Pôle d’analyses et de recherche de Normandie
11 U2RM - Unité de Recherche Risques Microbiens
12 Institute of Veterinary Medicine
13 UGENT - Universiteit Gent = Ghent University = Université de Gand
14 University of Waikato [Hamilton]
15 Massey University
16 University of Melbourne
17 Japan Racing Association
18 Clinica Equina Buenos Aires
19 Department of Biomedical Sciences and Veterinary Public Health
20 Labor Dr Böse GmbH
21 UCD - University College Dublin [Dublin]
22 IEC - Irish Equine Centre
23 KVI - Kimron Veterinary Institute
24 Facultad de Veterinaria, Universidad Complutense
25 Exopol Zaragoza
26 Al Khalediah Equine Hospital
27 UNICAM - Università degli Studi di Camerino = University of Camerino
28 Redwings Horse Sanctuary
29 Royal Society for the Prevention of Cruelty to Animals
30 Weatherford Equine Medical Centre
31 Centre for Genomic Pathogen Surveillance
32 Big Data Institute - Nuffield Department of Medicine [Oxford, UK]
33 Microbiotica Limited
34 University of St Andrews [Scotland]
35 Intervacc AB
2 Technology Networks
3 Xampla
4 FU - Free University of Berlin
5 CAM - University of Cambridge [UK]
6 Department of Veterinary Science, Gluck Equine Research Center
7 CVRL - Central Veterinary Research Laboratory
8 Emirates Racing Authority
9 Animal Health Service (GD)
10 LABÉO - LABÉO, Pôle d’analyses et de recherche de Normandie
11 U2RM - Unité de Recherche Risques Microbiens
12 Institute of Veterinary Medicine
13 UGENT - Universiteit Gent = Ghent University = Université de Gand
14 University of Waikato [Hamilton]
15 Massey University
16 University of Melbourne
17 Japan Racing Association
18 Clinica Equina Buenos Aires
19 Department of Biomedical Sciences and Veterinary Public Health
20 Labor Dr Böse GmbH
21 UCD - University College Dublin [Dublin]
22 IEC - Irish Equine Centre
23 KVI - Kimron Veterinary Institute
24 Facultad de Veterinaria, Universidad Complutense
25 Exopol Zaragoza
26 Al Khalediah Equine Hospital
27 UNICAM - Università degli Studi di Camerino = University of Camerino
28 Redwings Horse Sanctuary
29 Royal Society for the Prevention of Cruelty to Animals
30 Weatherford Equine Medical Centre
31 Centre for Genomic Pathogen Surveillance
32 Big Data Institute - Nuffield Department of Medicine [Oxford, UK]
33 Microbiotica Limited
34 University of St Andrews [Scotland]
35 Intervacc AB
Albertine Léon
- Fonction : Auteur
- PersonId : 735111
- IdHAL : albertine-leon
- ORCID : 0000-0003-3151-4947
- IdRef : 112450806
Résumé
The equine disease strangles, which is characterized by the formation of abscesses in the lymph nodes of the head and neck, is one of the most frequently diagnosed infectious diseases of horses around the world. The causal agent, Streptococcus equi subspecies equi , establishes a persistent infection in approximately 10 % of animals that recover from the acute disease. Such ‘carrier’ animals appear healthy and are rarely identified during routine veterinary examinations pre-purchase or transit, but can transmit S. equi to naïve animals initiating new episodes of disease. Here, we report the analysis and visualization of phylogenomic and epidemiological data for 670 isolates of S. equi recovered from 19 different countries using a new core-genome multilocus sequence typing (cgMLST) web bioresource. Genetic relationships among all 670 S. equi isolates were determined at high resolution, revealing national and international transmission events that drive this endemic disease in horse populations throughout the world. Our data argue for the recognition of the international importance of strangles by the Office International des Épizooties to highlight the health, welfare and economic cost of this disease. The Pathogenwatch cgMLST web bioresource described herein is available for tailored genomic analysis of populations of S. equi and its close relative S. equi subspecies zooepidemicus that are recovered from horses and other animals, including humans, throughout the world. This article contains data hosted by Microreact .
Origine | Publication financée par une institution |
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