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Journal Articles IUBMB Life Year : 2019

Chromogranin A in the early steps of the neurosecretory pathway

Abstract

Chromogranin A (CgA) is a soluble glycoprotein stored with hormones and neuropeptides in secretory granules (SG) of most (neuro)endocrine cells and neurons. Since its discovery in 1967, many studies have reported its structural characteristics, biological roles, and mechanisms of action. Indeed, CgA is both a precursor of various biologically active peptides and a granulogenic protein regulating the storage and secretion of hormones and neuropeptides. This review emphasizes the findings and theoretical concepts around the CgAlinked molecular machinery controlling hormone/neuropeptide aggregation and the interaction of CgA-hormone/neuropeptide aggregates with the trans- Golgi membrane to allow hormone/neuropeptide targeting and SG biogenesis. We will also discuss the intriguing alteration of CgA expression and secretion in various neurological disorders, which could provide insights to elucidate the molecular mechanisms underlying these pathophysiological conditions.

Dates and versions

hal-02427300 , version 1 (03-01-2020)

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Fanny Laguerre, Youssef Anouar, Maite Montero-Hadjadje. Chromogranin A in the early steps of the neurosecretory pathway. IUBMB Life, 2019, ⟨10.1002/iub.2218⟩. ⟨hal-02427300⟩
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