Sequential friedel-crafts-type α-amidoalkylation/intramolecular hydroarylation Distinct advantage of combined Tf2NH/cationic LAu(I) as a consecutive or binary bicatalytic system
Abstract
The combined use of Tf2NH and L(Au)+X- as a dual or binary catalytic system clearly improves the efficiency and enlarges the scope of the tandem intermolecular Friedel-Crafts α-amidoalkylation/intramolecular hydroarylation sequence, compared to an "all gold" multicatalysis approach. © 2015 American Chemical Society.