Toward the synthesis of 6-hydroxyquinoline starting from glycerol via improved microwave-assisted modified Skraup reaction - Normandie Université Access content directly
Journal Articles Catalysis Communications Year : 2014

Toward the synthesis of 6-hydroxyquinoline starting from glycerol via improved microwave-assisted modified Skraup reaction

Abstract

An efficient and modified Skraup reaction and Bamberger rearrangement in neat water were developed using nitrobenzene and an inexpensive, abundant and environmentally-friendly glycerol under microwave irradiation conditions was furnish regioselectively to the 6-hydroxyquinoline. The target compound was obtained in 77% yield via efficient domino reaction with a “one pot eleven steps”.
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Dates and versions

hal-02409886 , version 1 (13-12-2019)

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Hanen Saggadi, Denis Luart, Nicolas Thiebault, Isabelle Polaert, Lionel Estel, et al.. Toward the synthesis of 6-hydroxyquinoline starting from glycerol via improved microwave-assisted modified Skraup reaction. Catalysis Communications, 2014, 44, pp.15-18. ⟨10.1016/j.catcom.2013.07.029⟩. ⟨hal-02409886⟩
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