Enantioselective synthesis of (2S)-2-(4-phosphonophenylmethyl)-3-aminopropanoic acid suitably protected for peptide synthesis - Normandie Université Access content directly
Journal Articles Tetrahedron Letters Year : 2002

Enantioselective synthesis of (2S)-2-(4-phosphonophenylmethyl)-3-aminopropanoic acid suitably protected for peptide synthesis

Abstract

Protected d-β-2-(4-phosphono) phenylalanine was prepared by a multistep synthesis, involving the diastereoselective alkylation of a chiral enolate. This new compound can be further incorporated into peptidic backbone by means of solid-phase peptide synthesis in order to synthesize short peptides adopting β-turn or α-helix conformations.

Dates and versions

hal-02385516 , version 1 (28-11-2019)

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Wang-Qing Liu, Catherine Olszowy, Laurent Bischoff, Christiane Garbay. Enantioselective synthesis of (2S)-2-(4-phosphonophenylmethyl)-3-aminopropanoic acid suitably protected for peptide synthesis. Tetrahedron Letters, 2002, 43 (8), pp.1417-1419. ⟨10.1016/S0040-4039(02)00004-7⟩. ⟨hal-02385516⟩
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