An alternative route to the proline derivative (2S,5R)-5-ethoxycarbonylmethyl-pyrrolidine-2-carboxylic acid from protected glutamic acid
Abstract
The synthesis of (2S,5R)-5-ethoxycarbonylmethyl-pyrrolidine-2-carboxylic acid was achieved in two steps, with an overall yield of 53%. This synthesis used Cbz-Glu-OBzl as the starting material and led to the titled compound with a d.e.>96%.