An alternative route to the proline derivative (2S,5R)-5-ethoxycarbonylmethyl-pyrrolidine-2-carboxylic acid from protected glutamic acid - Normandie Université Access content directly
Journal Articles Tetrahedron Letters Year : 2003

An alternative route to the proline derivative (2S,5R)-5-ethoxycarbonylmethyl-pyrrolidine-2-carboxylic acid from protected glutamic acid

Abstract

The synthesis of (2S,5R)-5-ethoxycarbonylmethyl-pyrrolidine-2-carboxylic acid was achieved in two steps, with an overall yield of 53%. This synthesis used Cbz-Glu-OBzl as the starting material and led to the titled compound with a d.e.>96%.

Dates and versions

hal-02385515 , version 1 (28-11-2019)

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Marie-Priscille Brun, Anne-Sophie Martin, Christiane Garbay, Laurent Bischoff. An alternative route to the proline derivative (2S,5R)-5-ethoxycarbonylmethyl-pyrrolidine-2-carboxylic acid from protected glutamic acid. Tetrahedron Letters, 2003, 44 (37), pp.7011-7013. ⟨10.1016/S0040-4039(03)01792-1⟩. ⟨hal-02385515⟩
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