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Journal Articles Tetrahedron Letters Year : 2007

Towards a biomimetic synthesis of barrenazine A

Abstract

We report herein a concise and biomimetic synthesis of a precursor of barrenazine A, a cytotoxic alkaloid. The C2-symmetry of this molecule suggested the dimerization of an aminoketone, as the precursor of the central core pyrazine. This compound was prepared by assembly of aspartic acid and glycine.

Dates and versions

hal-02385028 , version 1 (28-11-2019)

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Frédéric Buron, Alain Turck, Nelly Plé, Laurent Bischoff, Francis Marsais. Towards a biomimetic synthesis of barrenazine A. Tetrahedron Letters, 2007, 48 (25), pp.4327-4330. ⟨10.1016/j.tetlet.2007.04.108⟩. ⟨hal-02385028⟩
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