Stereocontrolled Solid-Phase Synthesis of a 90-Membered Library of Indoline-Alkaloid-like Polycycles from an Enantioenriched Aminoindoline Scaffold - Normandie Université Access content directly
Journal Articles Angewandte Chemie International Edition Year : 2005

Stereocontrolled Solid-Phase Synthesis of a 90-Membered Library of Indoline-Alkaloid-like Polycycles from an Enantioenriched Aminoindoline Scaffold

Abstract

A library of tricyclic derivatives, similar to indoline alkaloids, has been generated by using a stereocontrolled, conjugate hetero‐Michael approach in both the solution and the solid phase (see scheme; P=protecting group, R=functional group). The mild reaction conditions that lead to the tricyclic derivatives, which contain β‐amino acid functionalities, are highly attractive.

Dates and versions

hal-02384481 , version 1 (28-11-2019)

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Zhonghong Gan, P. Thirupathi Reddy, Sophie Quévillon, Samuel Couve-Bonnaire, Prabhat Arya. Stereocontrolled Solid-Phase Synthesis of a 90-Membered Library of Indoline-Alkaloid-like Polycycles from an Enantioenriched Aminoindoline Scaffold. Angewandte Chemie International Edition, 2005, 44 (9), pp.1366-1368. ⟨10.1002/anie.200462298⟩. ⟨hal-02384481⟩

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