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Article Dans Une Revue Organic Letters Année : 2012

Substitution Effect on the One- and Two-photon Sensitivity of DMAQ “Caging” Groups

Résumé

The systematic SAR study of a "caging" group showed a strong influence of the position of the donor dimethylamino group on the efficiency of photolysis of the DMAQ (2-hydroxymethylene-(N,N-dimethylamino)quinoline) caged acetate under one-photon near-UV or two-photon near-IR excitation. Photorelease of l-glutamate by the most efficient 8-DMAQ derivative strongly and efficiently activated glutamate receptors, generating large, fast rising responses similar to those elicited by glutamate photoreleased from the widely used MNI-caged glutamate.
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Dates et versions

hal-02383436 , version 1 (27-11-2019)

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Morgane Petit, Christine Tran, Thomas Roger, Thibault Gallavardin, Hamid Dhimane, et al.. Substitution Effect on the One- and Two-photon Sensitivity of DMAQ “Caging” Groups. Organic Letters, 2012, 14 (24), pp.6366-6369. ⟨10.1021/ol3031704⟩. ⟨hal-02383436⟩
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