Synthesis and biological testing of 3-phenyloctahydro-pyrimido[1,2- a ]- s -triazine derivatives - Normandie Université Access content directly
Journal Articles Journal of Heterocyclic Chemistry Year : 2002

Synthesis and biological testing of 3-phenyloctahydro-pyrimido[1,2- a ]- s -triazine derivatives

Abstract

A series of 46 3‐phenyloctahydropyrimido[1,2‐a]‐s–triazine derivatives were synthesized. This synthesis was performed via iminodimethylation of dialkylated 2‐aminopyrimidinedione synthons by substituted primary arylamines. In vitro pharmacological evaluation of these compounds is reported. One of them exhibited antifungal activity against Microsporum canis (10−65010−5 mol/L), and another showed affinity for serotoninergic 5‐HT1A and 5‐HT2b receptors (10−85010−7 mol/L).

Dates and versions

hal-02375741 , version 1 (22-11-2019)

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Line Lucry, Ferdinand Enoma, François Estour, Sabine Ménager, Olivier Lafont, et al.. Synthesis and biological testing of 3-phenyloctahydro-pyrimido[1,2- a ]- s -triazine derivatives. Journal of Heterocyclic Chemistry, 2002, 39 (4), pp.663-670. ⟨10.1002/jhet.5570390410⟩. ⟨hal-02375741⟩
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