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Journal Articles recent patents on anti-infective drug discovery Year : 2016

Hybolites Revisited


Background: Hyperstructures are large assemblies of molecules and macro-molecules that perform functions such as metabolism (including RNA and protein synthesis and degradation), transport, DNA replication, cell division, signalling and chemotaxis. Methods: Such hyperstructures might be manipulated by hybrid metabolites or hybolites made by a pairwise, covalently linked combination of the thousands of small molecules involved in metabolism and signalling. Results: Here, we review recent evidence for hyperstructures in prokaryotes and for interactions between hy-perstructures as a determinant of the phenotype. We also mention extending hybolite therapy to eukaryotes, consider new designs for hybolites, and discuss relevant patents.
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hal-02352531 , version 1 (13-11-2019)


  • HAL Id : hal-02352531 , version 1


Victor Norris, Cécile Verrier, Marc Feuilloley. Hybolites Revisited. recent patents on anti-infective drug discovery, 2016, 11, pp.16 - 31. ⟨hal-02352531⟩
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