Synthesis of 2-, 3-, and 4-Substituted Pyrido[2,3-b]indoles by C-N, C-O, and C-C(sp) Bond Formation - Normandie Université Access content directly
Journal Articles European Journal of Organic Chemistry Year : 2010

Synthesis of 2-, 3-, and 4-Substituted Pyrido[2,3-b]indoles by C-N, C-O, and C-C(sp) Bond Formation

Abstract

The synthesis of 2-, 3-, and 4-substituted alpha-carbolines is described starting from the corresponding chloropyrido[2,3-b]-indoles by Buchwald-Hartwig and Sonogashira cross-coupling reactions. Regioselective Sonogashira reactions on 2,4-dichloropyrido[2,3-b]indoles are also presented as an efficient route to unsymmetrically 2,4-disubstituted alpha-carbolines.

Dates and versions

hal-02351724 , version 1 (06-11-2019)

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Cédric Schneider, David Goyard, David Gueyrard, Benoît Joseph, Peter Goekjian. Synthesis of 2-, 3-, and 4-Substituted Pyrido[2,3-b]indoles by C-N, C-O, and C-C(sp) Bond Formation. European Journal of Organic Chemistry, 2010, 2010 (34), pp.6665-6677. ⟨10.1002/ejoc.201000795⟩. ⟨hal-02351724⟩
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