Neuropeptide Y and α-MSH Circadian Levels in Two Populations with Low Body Weight: Anorexia Nervosa and Constitutional Thinness - Normandie Université Access content directly
Journal Articles PLoS ONE Year : 2015

Neuropeptide Y and α-MSH Circadian Levels in Two Populations with Low Body Weight: Anorexia Nervosa and Constitutional Thinness

Abstract

Context Anorexia nervosa (AN) presents an adaptive appetite regulating profile including high levels of ghrelin and 26RFa (orexigenic) and low levels of leptin and PYY (anorexigenic). However , this adaptive mechanism is not effective in promoting food intake. The NPY/proopiome-lanocortin (POMC) system plays a crucial role in the regulation of feeding behavior as NPY is the most potent orexigenic neuropeptide identified so far and as the POMC-derived pep-tide α-MSH drastically reduces food intake, and this peptidergic system has not been thoroughly studied in AN. Objective The aim of the present study was thus to investigate whether a dysfunction of the NPY/ POMC occurs in two populations with low body weight, AN and constitutional thinness (CT). Design and Settings This was a cross-sectional study performed in an endocrinological unit and in an academic laboratory. Investigated Subjects Three groups of age-matched young women were studied: 23 with AN (AN), 22 CT and 14 normal weight controls.
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hal-02330473 , version 1 (15-05-2020)

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Bogdan Galusca, Gaëtan Prévost, Natacha Germain, Isabelle Dubuc, Yiin Ling, et al.. Neuropeptide Y and α-MSH Circadian Levels in Two Populations with Low Body Weight: Anorexia Nervosa and Constitutional Thinness. PLoS ONE, 2015, 10 (3), pp.e0122040. ⟨10.1371/journal.pone.0122040⟩. ⟨hal-02330473⟩
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