Effects of aging on structure and stability of TiO2 nanoparticle-containing oil-in-water emulsions - Normandie Université Access content directly
Journal Articles International Journal of Pharmaceutics Year : 2014

Effects of aging on structure and stability of TiO2 nanoparticle-containing oil-in-water emulsions

Abstract

Formulations incorporating different cosmetic grade TiO 2 nanoparticles were developed according to a self-produced protocol on the basis of typical sunscreen cream oil-in-water emulsions. Role of nanopar-ticles and, more specifically, the impact of two different lipophilic surface treatments on microstructure and stability of the formulations were assessed. Aging of formulations was performed under classical conditions at room temperature or under accelerated conditions at 50 • C, with or without TiO 2 , and was characterized by several tools such as rheology, microscopy, and particle size measurements. Changes in emulsion stability and aggregation state of nanoparticles were followed over time. Destabilization phenomena were identified: under accelerated aging, the formulation without nanoparticles underwent a coalescence occurrence whereas the formulation incorporating nanoparticles was subjected to aggregation of the colloidal particles. Besides, TiO 2 nanoparticles strongly affected the particle-droplets interactions and thus modified the emulsion microstructure with a coating-dependent effect: destabilization mechanisms occur more rapidly with alumina (and) triethoxycaprylylsilane (coating 1) TiO 2 nanoparticles as compared to alumina (and) isopropyl titanium triisostearate (and) triethoxycaprylylsi-lane crosspolymer (coating 2) nanoparticles.
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Dates and versions

hal-02310811 , version 1 (24-10-2019)

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Manon Rossano, Nicolas Hucher, Celine Picard, Daniel Colletta, Frank Le Foll, et al.. Effects of aging on structure and stability of TiO2 nanoparticle-containing oil-in-water emulsions. International Journal of Pharmaceutics, 2014, 461 (1-2), pp.89-96. ⟨10.1016/j.ijpharm.2013.11.039⟩. ⟨hal-02310811⟩
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