Oxy-PAHs: occurrence in the environment and potential genotoxic/mutagenic risk assessment for human health - Normandie Université Access content directly
Journal Articles Critical Reviews in Toxicology Year : 2019

Oxy-PAHs: occurrence in the environment and potential genotoxic/mutagenic risk assessment for human health

Abstract

Structurally modified polycyclic aromatic hydrocarbons (PAHs) such as nitrated PAHs (nitro-PAHs) and oxygenated PAHs (oxy-PAHs) can be incriminated in the total toxicity of polycyclic aromatic compounds (PACs) fraction in the environment. Compared to nitro-PAHs, oxy-PAHs have been poorly studied. Oxy-PAHs covers compounds with different moieties such as polycyclic aromatic ketones (PAKs) and polycyclic aromatic quinones (PAQs). In this review, we have compiled exhaustively all the data available on the sources, the fate, and the occurrence of oxy-PAHs focusing on the most ubiquitous ones in the environment, ie PAKs and PAQs. Data concerning their genotoxicity, mutagenicity and tumor promotion potential for humans are also provided based on the mode-of-action analysis framework. Mutagenicity results based on the limited number of oxy-PAHs tested, are unequivocal on the concern they represent. Their omission in mutagenic/carcinogenic risk has caused a dramatic underestimation of cancer risk. On the basis of environmental and genotoxicological data, we suggest prioritized 4 major oxy-PAHs molecules in ecotoxicological and toxicological studies, namely 6 H-benzo[cd]pyren- 6-one (BPO), 7,12-benz[a]anthracenequinone (BAQ), 5,12-naphthacenequinone (NCQ) and 11 H-benzo[b]fluoren-11-one (B[b]FO). We also propose to develop biomarkers of exposure and/or risk for these compounds, for example by quantification of DNA adducts.
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Dates and versions

hal-02296899 , version 1 (04-12-2019)

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Adeline Clerge, Jeremie Le Goff, Claire Lopez, Jerome Ledauphin, Raphaël Delépée. Oxy-PAHs: occurrence in the environment and potential genotoxic/mutagenic risk assessment for human health. Critical Reviews in Toxicology, 2019, pp.1-27. ⟨10.1080/10408444.2019.1605333⟩. ⟨hal-02296899⟩
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