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Journal Articles European Journal of Pharmacology Year : 2005

Reduced appetite for caffeine in adenosine A(2A) receptor knockout mice

Abstract

Adenosine A(2A) receptor knockout mice (A(2A)R KO) were compared to wild-type controls (A(2A)R WT) in a caffeine intake paradigm. When mice had ad libitum access to caffeine (0.3 g/l) and water in a two-bottle paradigm for 12 consecutive days, adenosine A(2A)R KO mice drank less caffeinated solution, demonstrating a reduced appetite for caffeine as compared to adenosine A(2A)R WT mice. These data reveal an important role for the adenosine A(2A) receptor in the appetitive properties of caffeine.

Dates and versions

hal-02185492 , version 1 (16-07-2019)

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Malika El Yacoubi, Catherine Ledent, Marc Parmentier, Jean Costentin, Jean-Marie Vaugeois. Reduced appetite for caffeine in adenosine A(2A) receptor knockout mice. European Journal of Pharmacology, 2005, 519 (3), pp.290-1. ⟨10.1016/j.ejphar.2005.07.022⟩. ⟨hal-02185492⟩
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