The Enterococcus faecalis superoxide dismutase is essential for its tolerance to vancomycin and penicillin - Normandie Université Access content directly
Journal Articles Journal of Antimicrobial Chemotherapy Year : 2009

The Enterococcus faecalis superoxide dismutase is essential for its tolerance to vancomycin and penicillin

Abstract

Enterococcus faecalis is a human commensal that has the ability to become a pathogen. Because of its ruggedness, it can persist in the hospital setting and cause serious nosocomial infections. E. faecalis can acquire multiple drug resistance determinants but is also intrinsically tolerant to a number of antibiotics, such as penicillin or vancomycin, meaning that these usually bactericidal drugs only exhibit a bacteriostatic effect. Recently, evidence has been presented that exposure to bactericidal antibiotics induced the production of reactive oxygen species in bacteria. Here, we studied the role of enzymes involved in the oxidative stress response in the survival of E. faecalis after antibiotic treatment.

Dates and versions

hal-02180970 , version 1 (11-07-2019)

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Alain Bizzini, Chen Zhao, Yanick Auffray, Axel Hartke. The Enterococcus faecalis superoxide dismutase is essential for its tolerance to vancomycin and penicillin. Journal of Antimicrobial Chemotherapy, 2009, 64 (6), pp.1196-1202. ⟨10.1093/jac/dkp369⟩. ⟨hal-02180970⟩
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