Genomic organization, structure, regulation and pathogenic role of pilus constituents in major pathogenic Streptococci and Enterococci - Normandie Université Access content directly
Journal Articles International Journal of Medical Microbiology Year : 2011

Genomic organization, structure, regulation and pathogenic role of pilus constituents in major pathogenic Streptococci and Enterococci

Abstract

Oligocomponent pilus structures, recently discovered in many important Gram-positive pathogens, represent a new class of virulence factors with adhesive and matrix protein-binding activity. Some of these proteins have emerged as very promising lead components of protein-based vaccines against Streptococci. These extended surface structures play key roles in host cell and tissue adherence, paracellular translocation, and biofilm formation of major Gram-positive pathogens such as Streptococcus pyogenes, S. agalactiae, S. pneumoniae as well as in opportunistic and nosocomial pathogens like Enterococci. Here, we discuss the similarities and differences of: (1) the genomic organization of the various regions encoding pilus proteins, (2) the number, type, and assembly of the proteins constituting the pili, (3) their expression and regulation mechanisms, (4) their role in bacterial virulence, and (5) their potential as vaccine candidate antigens.
No file

Dates and versions

hal-02180944 , version 1 (11-07-2019)

Identifiers

Cite

Bernd Kreikemeyer, Gustavo Gámez, Immaculada Margarit, Jean-Christophe Giard, Sven Hammerschmidt, et al.. Genomic organization, structure, regulation and pathogenic role of pilus constituents in major pathogenic Streptococci and Enterococci. International Journal of Medical Microbiology, 2011, 301 (3), pp.240-251. ⟨10.1016/j.ijmm.2010.09.003⟩. ⟨hal-02180944⟩
107 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More