Well-Defined Phosphine-Free Iron-Catalyzed N -Ethylation and N -Methylation of Amines with Ethanol and Methanol - Normandie Université Access content directly
Journal Articles Organic Letters Year : 2018

Well-Defined Phosphine-Free Iron-Catalyzed N -Ethylation and N -Methylation of Amines with Ethanol and Methanol

Abstract

An iron(0) complex bearing a cyclopentadienone ligand catalyzed N-methylation and N-ethylation of aryl and aliphatic amines with methanol or ethanol in mild and basic conditions through a hydrogen autotransfer borrowing process is reported. A broad range of aromatic and aliphatic amines underwent mono- or dimethylation in high yields. DFT calculations suggest molecular hydrogen acts not only as a reducing agent but also as an additive to displace thermodynamic equilibria.
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hal-02159935 , version 1 (19-06-2019)

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Alexis Lator, Sylvain Gaillard, Albert Poater, Jean-Luc Renaud. Well-Defined Phosphine-Free Iron-Catalyzed N -Ethylation and N -Methylation of Amines with Ethanol and Methanol. Organic Letters, 2018, 20 (19), pp.5985-5990. ⟨10.1021/acs.orglett.8b02080⟩. ⟨hal-02159935⟩
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