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Journal Articles Angewandte Chemie International Edition Year : 2016

An Electrophilic Reagent for the Direct Introduction of the SCF2PO(OEt)2Group to Molecules

Abstract

An unprecedented electrophilic difluoromethylthiolating reagent (MesNHSCF2PO(OEt)2) was designed. Under mild and metal‐free conditions, this new reagent reacted with various nucleophiles, thus offering an efficient and operationally simple tool for the construction of C−SCF2PO(OR)2, N−SCF2PO(OR)2, and S−SCF2PO(OR)2 bonds. Finally, thanks to this new methodology, the synthesis of the non‐stereoidal anti‐inflammatory diflumidone was achieved.

Dates and versions

hal-02046245 , version 1 (22-02-2019)

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Heng-Ying Xiong, Alexandre Bayle, Xavier Pannecoucke, Tatiana Besset. An Electrophilic Reagent for the Direct Introduction of the SCF2PO(OEt)2Group to Molecules. Angewandte Chemie International Edition, 2016, 55 (43), pp.13490-13494. ⟨10.1002/anie.201607231⟩. ⟨hal-02046245⟩
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