Straightforward synthesis of tri- and tetra-substituted 3-trifluoromethylfurans by heterocyclization reaction of perfluoroketene dithioacetals - Normandie Université Access content directly
Journal Articles Tetrahedron Year : 2016

Straightforward synthesis of tri- and tetra-substituted 3-trifluoromethylfurans by heterocyclization reaction of perfluoroketene dithioacetals

Abstract

Various 2-ethylsulfanyl-3-trifluoromethylfurans were obtained, in moderate to good yields, using a two-step procedure, from perfluoroketene dithioacetals as starting materials. Reaction tolerated a large variety of substituents on the furan nucleus. Mechanism of cyclization was also proposed based on the electronic properties of aryl and heteroaryl substituents.
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hal-02046201 , version 1 (22-02-2019)

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Clément de Saint Jores, Ivan Mukan, Tatyana Yegorova, Dominique Harakat, J.-P. Bouillon. Straightforward synthesis of tri- and tetra-substituted 3-trifluoromethylfurans by heterocyclization reaction of perfluoroketene dithioacetals. Tetrahedron, 2016, 72 (43), pp.6807-6814. ⟨10.1016/j.tet.2016.09.009⟩. ⟨hal-02046201⟩
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