Efficient and Direct Synthesis of γ‐Amino‐α,β‐Unsaturated Amides by Catalyzed Allylic Substitution of α‐Fluoroenamides: Toward to Synthesis of Hybrid Peptides and Indolizidines
Résumé
A variety of γ‐amino‐α,β‐unsaturated amides have been synthesized from readily available α‐fluoroenamides precursors via an unprecedented intermolecular and intramolecular conjugative catalytic amination process. These γ‐amino‐α,β‐unsaturated amides are useful intermediates for accessing rarely synthesized hybrid peptides, αγα sequences, and various classes of alkaloids containing a pyrrolidine ring, as illustrated by total synthesis of the indolizidine alkaloid coniceine.