An optimized procedure for direct access to 1H-indazole-3-carboxaldehyde derivatives by nitrosation of indoles - Normandie Université Access content directly
Journal Articles RSC Advances Year : 2018

An optimized procedure for direct access to 1H-indazole-3-carboxaldehyde derivatives by nitrosation of indoles

Abstract

Indazole derivatives are currently drawing more and more attention in medicinal chemistry as kinase inhibitors. 1H-indazole-3-carboxaldehydes are key intermediates to access to a variety of polyfunctionalized 3-substituted indazoles. We report here a general access to this motif, based on the nitrosation of indoles in a slightly acidic environment. These very mild conditions allow the conversion of both electron-rich and electron-deficient indoles into 1H-indazole-3-carboxaldehydes.

Dates and versions

hal-02024488 , version 1 (19-02-2019)

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Arnaud Chevalier, Abdelaaziz Ouahrouch, Alexandre Arnaud, Thibault Gallavardin, Xavier Franck. An optimized procedure for direct access to 1H-indazole-3-carboxaldehyde derivatives by nitrosation of indoles. RSC Advances, 2018, 8 (24), pp.13121-13128. ⟨10.1039/c8ra01546e⟩. ⟨hal-02024488⟩
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