MRI probes based on C6-peracetate β-cyclodextrins: Synthesis, gadolinium complexation and in vivo relaxivity studies - Normandie Université Access content directly
Journal Articles Polyhedron Year : 2018

MRI probes based on C6-peracetate β-cyclodextrins: Synthesis, gadolinium complexation and in vivo relaxivity studies

Abstract

The initial synthesis of two β-cyclodextrin derivatives bearing seven carboxylate ligands was optimized in order to improve the production of contrast agents. A speciation study using potentiometric analysis was performed on a gadolinium(III) complex. The in vivo myocardic activity was evaluated on mice. This study highlights the best efficiency for the cyclodextrin derivative having free hydroxyl groups and validated the biomedical potential of the flexible cyclodextrin scaffold as a cardiac MRI probe.
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hal-02024474 , version 1 (19-02-2019)

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Anais Biscotti, Cécile Barbot, Lionel Nicol, Paul Mulder, Célia Sappei, et al.. MRI probes based on C6-peracetate β-cyclodextrins: Synthesis, gadolinium complexation and in vivo relaxivity studies. Polyhedron, 2018, 148, pp.32-43. ⟨10.1016/j.poly.2018.03.013⟩. ⟨hal-02024474⟩
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