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Journal Articles Molecular & Cellular Oncology Year : 2016

Modeling intratumor heterogeneity through CRISPR-barcodes

Abstract

We have devised a barcoding strategy to recapitulate cancer evolution through the emergence of subclonal mutations of interest, whose effects can be monitored in a dynamic manner. This approach can be easily adapted for a variety of applications, including combined modeling of multiple mechanisms of drug resistance or repair of oncogenic driver mutations in addicted cancer cells.

Dates and versions

hal-02017522 , version 1 (23-07-2019)

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Alexis Guernet, Stuart A. Aaronson, Youssef Anouar, Luca Grumolato. Modeling intratumor heterogeneity through CRISPR-barcodes. Molecular & Cellular Oncology, 2016, 3 (6), pp.e1227894. ⟨10.1080/23723556.2016.1227894⟩. ⟨hal-02017522⟩
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