Identification of 26RFa from Frog Brain: A Novel Hypothalamic Neuropeptide with Orexigenic Activity in Mammals - Normandie Université Access content directly
Journal Articles Annals of the New York Academy of Sciences Year : 2005

Identification of 26RFa from Frog Brain: A Novel Hypothalamic Neuropeptide with Orexigenic Activity in Mammals

Abstract

In the present study, we report the identification, in the frog brain, of a novel neuropeptide, termed 26RFa, that belongs to the RFamide peptide family. The cDNAs encoding the precursors for 26RFa have been characterized in human and rats. In rats, prepro-26RFa mRNA is expressed exclusively in two hypothalamic nuclei involved in the control of feeding behavior. Intracerebroventricular injection of 26RFa in mice induced a dose-dependent increase in food consumption. Taken together, these data indicate that 26RFa is a novel neuropeptide that may have important biological functions in vertebrates.

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hal-01960805 , version 1 (19-12-2018)

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Nicolas Chartrel, Federica Bruzzone, Cynthia Dujardin, Jérôme Leprince, Helene Tollemer, et al.. Identification of 26RFa from Frog Brain: A Novel Hypothalamic Neuropeptide with Orexigenic Activity in Mammals. Annals of the New York Academy of Sciences, 2005, 1040 (1), pp.80-83. ⟨10.1196/annals.1327.009⟩. ⟨hal-01960805⟩
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