Late-Stage Sulfoximination: Improved Synthesis of the Anticancer Drug Candidate Atuveciclib - Normandie Université Access content directly
Journal Articles Synthesis: Journal of Synthetic Organic Chemistry Year : 2019

Late-Stage Sulfoximination: Improved Synthesis of the Anticancer Drug Candidate Atuveciclib

Abstract

An efficient synthesis of racemic atuveciclib was accomplished in five steps with an excellent 51% overall yield, using cheap reagents and mild reaction conditions. The key sulfoximination reaction was realized during the last step of the synthesis from the corresponding sulfide.
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Dates and versions

hal-01926262 , version 1 (19-11-2018)

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Thomas Glachet, Xavier Franck, Vincent Reboul. Late-Stage Sulfoximination: Improved Synthesis of the Anticancer Drug Candidate Atuveciclib. Synthesis: Journal of Synthetic Organic Chemistry, 2019, 51 (4), pp.971-975. ⟨10.1055/s-0037-1610316⟩. ⟨hal-01926262⟩
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