Curdlan microspheres. Synthesis, characterization and interaction with proteins (enzymes, vaccines) - Normandie Université Access content directly
Journal Articles International Journal of Biological Macromolecules Year : 2009

Curdlan microspheres. Synthesis, characterization and interaction with proteins (enzymes, vaccines)

Abstract

Microparticles of curdlan, synthesized through crosslinking with epichlorohydrin in organic suspension media, were chemically modified with the aim of introducing strongly and/or weakly acidic anionic and palmitoyl hydrophobic groups. Microparticles of both curdlan and curdlan derivatives were physico-chemically characterized. Study of the interaction with enzymes, such as lysozyme, and vaccines, such as tetanus anatoxin, showed a co-operative protein retention effect, induced by electrostatic and hydrophobic forces. The results of the in vitro release studies on support–protein complexes recommend them as potential controlled release systems.
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hal-01866796 , version 1 (03-09-2018)

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Georgeta Mocanu, Doina Mihai, Misu Moscovici, Luc Picton, Didier Lecerf. Curdlan microspheres. Synthesis, characterization and interaction with proteins (enzymes, vaccines). International Journal of Biological Macromolecules, 2009, 44 (3), pp.215 - 221. ⟨10.1016/j.ijbiomac.2008.12.005⟩. ⟨hal-01866796⟩
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