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Journal Articles Chemistry - A European Journal Year : 2018

Iron-Catalyzed Chemoselective Reduction of α,β-Unsaturated Ketones

Abstract

An iron‐catalyzed chemo‐ and diastereoselective reduction of α,β‐unsaturated ketones into the corresponding saturated ketones in mild reaction conditions is reported herein. DFT calculations and experimental work underline that transfer hydride reduction is a more facile process than hydrogenation, unveiling the fundamental role of the base.
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hal-01850332 , version 1 (27-07-2018)

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Alexis Lator, Sylvain Gaillard, Albert Poater, Jean-Luc Renaud. Iron-Catalyzed Chemoselective Reduction of α,β-Unsaturated Ketones. Chemistry - A European Journal, 2018, 24 (22), pp.5770 - 5774. ⟨10.1002/chem.201800995⟩. ⟨hal-01850332⟩
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