An organocatalytic access to spiro[4.5]decanes and spiro[4.6]undecanes containing aminolactones and 3-aminopyrrolidines - Normandie Université Access content directly
Journal Articles Synthesis: Journal of Synthetic Organic Chemistry Year : 2015

An organocatalytic access to spiro[4.5]decanes and spiro[4.6]undecanes containing aminolactones and 3-aminopyrrolidines

Abstract

The organocatalyzed Mannich coupling of cyclic carboxaldehydes allowed the concise and simple preparation of spirocyclic aminolactones. Their conversion into pharmaceutically relevant spiro[4.5]cyclic and spiro[4.6]cyclic 3-aminopyrrolidines is also described.
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hal-01848013 , version 1 (24-07-2018)

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M. Cormier, A. Chardon, J. Blanchet, J. Rouden, Jacques Maddaluno, et al.. An organocatalytic access to spiro[4.5]decanes and spiro[4.6]undecanes containing aminolactones and 3-aminopyrrolidines. Synthesis: Journal of Synthetic Organic Chemistry, 2015, 47 (17), pp.2549-2553. ⟨10.1055/s-0034-1380146⟩. ⟨hal-01848013⟩
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