Ectopic Expression of Cyclin D1 Impairs the Proliferation and Enhances the Apoptosis of a Murine Lymphoid Cell Line - Normandie Université Access content directly
Journal Articles Cell Death and Differentiation Year : 2001

Ectopic Expression of Cyclin D1 Impairs the Proliferation and Enhances the Apoptosis of a Murine Lymphoid Cell Line

Abstract

Cyclin D1, a key regulator of the cell cycle, acts as an oncogene when over-expressed in several types of cancer. In some B-chronic lymphoproliferative disorders, the over-expression of cyclin D1 protein is thought to confer a proliferative phenotype. We have generated BaF3 pro-B cell derivatives in which cyclin D1 can be induced rapidly and reversibly in a dose-dependent manner by the hormone muristerone A. When non-expressing clones displayed the same proliferative capacity as the parental cell line, in the sub-clones, a moderate induction of cyclin D1 lengthened the proliferation rate. The over-expression of cyclin D1 had the same effects on cell proliferation but also led ultimately to cell death by apoptosis. The induction of cyclin D1 in growth factor-deprived cells as well as in anticancer drug-treated cells also reinforced the magnitude of apoptosis. Thus, the expression of cyclin D1 in lymphoid cells does not confer a proliferative advantage but rather alters the response of cells towards apoptotic stimuli in a p53-independent manner. Cell Death and Differentiation (2001) 8, 51–62.

Dates and versions

hal-01762037 , version 1 (09-04-2018)

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Duquesne F, Florent M, Roué G, Troussard X, Brigitte Sola. Ectopic Expression of Cyclin D1 Impairs the Proliferation and Enhances the Apoptosis of a Murine Lymphoid Cell Line. Cell Death and Differentiation, 2001, 8, p. 51-62. ⟨10.1038/sj.cdd.4400768⟩. ⟨hal-01762037⟩
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