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Journal Articles Drug Discovery Today Year : 2023

New trends for osteoarthritis: Biomaterials, models and modeling

Abstract

The burden of osteoarthritis (OA), one of the major causes of functional disabilities in humans and animals, continues to increase worldwide while no disease-modifying OA drugs (DMOADs) that either slow down or reverse disease progression have been made available. Here, we provide a brief overview of recent advances in: designing new OA drug delivery approaches, focusing on lubrication-based biomaterials and drug delivery systems, such as hydrogels, liposomes, dendrimers, micro- and nanoparticles; using either large (horse) or small (zebrafish) relevant animal models to evaluate new therapeutic strategies; and OA in vitro modeling, focusing on 3D (organoid) models of cartilage regarding the Replace, Reduce and Refine (3R) principle of animal experimentation.
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hal-03975532 , version 1 (06-02-2023)

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Seng Manivong, Aurélie Cullier, Fabrice Audigié, Xavier Banquy, Florina Moldovan, et al.. New trends for osteoarthritis: Biomaterials, models and modeling. Drug Discovery Today, 2023, 28 (3), pp.103488. ⟨10.1016/j.drudis.2023.103488⟩. ⟨hal-03975532⟩
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