Characterization of Unknown Solid States of the Drug Substance Quinacrine Dihydrochloride: Two Anhydrous Forms and a Tetrahydrate Revealed - Normandie Université Access content directly
Journal Articles Crystal Growth & Design Year : 2020

Characterization of Unknown Solid States of the Drug Substance Quinacrine Dihydrochloride: Two Anhydrous Forms and a Tetrahydrate Revealed

Abstract

A complete solid-state study of the drug quinacrine dihydrochloride has highlighted the existence of two anhydrous phases and a tetrahydrate form, using water sorption experiments, thermal analysis techniques, and crystallographic studies. The tetrahydrate crystal obtained by crystal growth from a water/dioxane (80:20, v/v) solution has been characterized by single-crystal X-ray diffraction at 123 K. This phase is a complex three-dimensional hydrogen bonding network, including four water molecules and two free chloride ions, and crystallizes in the P1 space group. Because no filiation between the two hydrates has been evidenced yet, the dehydration–rehydration mechanism has been evaluated for the present study as a destructive–reconstructive process. Two related anhydrous phases were also characterized by X-ray powder diffraction and thermal analysis.
No file

Dates and versions

hal-02962502 , version 1 (09-10-2020)

Identifiers

Cite

Romain Rotival, Stéphane Massip, Yohann Cartigny, Philippe Négrier, Yohann Corvis, et al.. Characterization of Unknown Solid States of the Drug Substance Quinacrine Dihydrochloride: Two Anhydrous Forms and a Tetrahydrate Revealed. Crystal Growth & Design, 2020, 20 (8), pp.5261-5268. ⟨10.1021/acs.cgd.0c00441⟩. ⟨hal-02962502⟩
52 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More