Synthesis of 6-Substituted Pyrido[2,3- b ]indoles by Electrophilic Substitution
Résumé
Regioselective electrophilic aromatic substitutions, acylation, bromination, and formylation, of unprotected pyrido[2,3-b]indole (α-carbolines) at the C-6 position are described. Alternative conditions for the nitration were investigated, which led to the unexpected appearance of the minor C-8 isomer.