SlyA regulator is involved in bile salts stress response of Enterococcus faecalis - Normandie Université Access content directly
Journal Articles FEMS Microbiology Letters Year : 2011

SlyA regulator is involved in bile salts stress response of Enterococcus faecalis

Abstract

SlyA is a newly transcriptional regulator identified in Enterococcus faecalis that is involved in the virulence, persistence in mouse kidneys and liver, and survival inside peritoneal macrophages. In this study we searched for environmental conditions that affect expression of the corresponding gene. Of the several stress conditions tested, only bile salts (0.08%) significantly induced transcription of slyA. In addition, the growth of ΔslyA mutant strain was significantly impaired in the presence of bile salts. To increase knowledge of SlyA regulon, real-time quantitative PCR was performed and revealed that expression of EF_3005, which encodes a choloylglycine hydrolase, is negatively regulated by SlyA.

Dates and versions

hal-02180934 , version 1 (11-07-2019)

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Charlotte Michaux, Cecilia Martini, Aurélie Hanin, Yanick Auffray, Axel Hartke, et al.. SlyA regulator is involved in bile salts stress response of Enterococcus faecalis. FEMS Microbiology Letters, 2011, 324 (2), pp.142-146. ⟨10.1111/j.1574-6968.2011.02390.x⟩. ⟨hal-02180934⟩
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