Copper-Mediated Introduction of the CF2PO(OEt)2 Motif: Scope and Limitations - Normandie Université Access content directly
Journal Articles Chemistry - A European Journal Year : 2017

Copper-Mediated Introduction of the CF2PO(OEt)2 Motif: Scope and Limitations

Abstract

Herein, a general procedure to access CF2PO(OEt)2‐containing molecules is reported. The reagent CuCF2PO(OEt)2 is accessible by a simple protocol and a broad range of substrates can be functionalised. The procedure allows the conversion of aryl diazonium salts, as well as aryl, heteroaryl, vinyl and alkynyl iodonium salts, into the corresponding fluorinated molecules at room temperature. Mechanistic studies were performed to gain a better understanding of the reaction pathway. Under similar conditions, vinyl and aryl iodides, allyl halides, and benzyl bromides were also functionalised, and the scope and limitations of the reaction were studied. Finally, the procedure was extended to disulfides to offer new access to SCF2PO(OEt)2‐containing molecules.
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Dates and versions

hal-02046283 , version 1 (22-02-2019)

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Maria V. Ivanova, Alexandre Bayle, Tatiana Besset, Xavier Pannecoucke, Thomas Poisson. Copper-Mediated Introduction of the CF2PO(OEt)2 Motif: Scope and Limitations. Chemistry - A European Journal, 2017, 23 (68), pp.17318-17338. ⟨10.1002/chem.201703542⟩. ⟨hal-02046283⟩
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